Clinical Effects of Ringers Lactate Versus Sterofundin/ Plasmalyte Solution in Patients With Sepsis
Clinical Effects of Ringers Lactate Versus Sterofundin/Plasmalyte Solution in Surgical Adult Patients With Sepsis; a Comparative Study in ICU Patients
CMH Lahore Medical College and Institute of Dentistry
82 participants
Nov 15, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to compare the clinical effects of using Ringer's Lactate and Sterofundin/ Plasmalyte as maintenance fluids in adult patients who have undergone abdominal surgery and are septic. The primary outcome will be the change in serum lactate levels. Secondary outcomes will include renal function parameters, qSOFA scores, and the incidence of postoperative complications within the first 72 hours following surgery.
Eligibility
Inclusion Criteria3
- Underwent Abdominal Surgery and postoperative length of stay is more than 24 hours
- ASA 1 to 4
- Diagnosis of sepsis (qSOFA score 2 or more)
Exclusion Criteria5
- Patients with Renal failure/hepatic failure/severe metabolic acidosis
- Patients requiring renal replacement therapy prior to enrolment
- Patients with suspected poisoning
- Pregnant women
- Patients having solitary kidney
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Interventions
A balanced crystalloid solution containing sodium, potassium, calcium, chloride, and lactate as a buffer. Used at a standard maintenance rate for adult postoperative patients.
A balanced, multi-electrolyte crystalloid solution containing acetate and malate as buffers instead of lactate. Designed to more closely match plasma electrolyte composition, with a lower chloride concentration than RL.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07239713