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RecruitingNot ApplicableNCT07244367

Maintenance Venetoclax in AML Fit Patients

Maintenance Venetoclax Based Therapy Post Complete Remission in AML Fit Patients

Sponsor

Sohag University

Enrollment

80 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Acute Myeloid Leukaemia (AML)

Summary

this study will explore the efficacy of maintenance SC cytarabine + venetoclax therapy as regard disease free survival (DFS) in AML fit patients who achieved CR after highly aggressive chemotherapy as bridge for BMT or if BMT will be delayed or canceled due to any other reason.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether the drug venetoclax (a targeted cancer drug already used in some blood cancers) can help maintain remission in younger adults with acute myeloid leukemia (AML) who are not immediately eligible for a bone marrow transplant after achieving remission with chemotherapy. **You may be eligible if...** - You are 18 to 60 years old - You have been diagnosed with AML - You have achieved complete remission after first-line or second-line chemotherapy - You are not immediately eligible for bone marrow transplant **You may NOT be eligible if...** - You have not achieved complete remission - You are under 18 or over 60 years old - You are immediately eligible and planned for bone marrow transplant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSC cytarabine +Venetoclax

SC Cytarabine (20 mg) administrated on days 1-7 ,,Venetoclax (100 mg ) administrated on days 1-7,,Voriconazole 200 mg 1x2 administrated on days , Best supportive care as needed . Up to 12 cycles or until patients undergo bone marrow transplantation

Locations(2)

Sohag university hospital

Sohag, Egypt

Sohag university

Sohag, Egypt

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NCT07244367

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