RecruitingNCT07244770

The Effects of Some Antihyperglycemic Drugs on Cognitive Function and Risk of Depression of Diabetic Patients

Sponsor

Beni-Suef University

Enrollment

300 participants

Start Date

Jan 1, 2025

Study Type

OBSERVATIONAL

Conditions

MCI

Summary

The study aims to investigate the effects of DPP-4 Is+ metformin versus SGLT2 Is + metformin on the risk of cognitive decline and depression in patients with T2DM.

Eligibility

Min Age: 55 Years

Inclusion Criteria3

\-
T2DM adult subjects (\>55 years old) will be eligible to participate.
Patients should be taking SGLT2Is+metformin or DDP4Is + metformin for at least 1 year to be eligible.

Exclusion Criteria1

Those with type1 diabetes or ketoacidosis, insulin therapy, end organ failure as chronic renal failure, liver, and heart failure, previous history of pancreatitis, history of Alzheimer's disease or any brain insult, and finally pregnant or lactating females will be excluded from the study.

Interventions

DRUGSGLT2 Is+METFORMIN

Patients administering SGLT2 Is+metformin added to their treatment for at least the past 12 months

DRUGDPP4 Is+metformin

Patients administering DPP4 I+ metformin added to their treatment for at least the past 12 months

DRUGControl group

patients administered their standard of care without any changes for the past 6 months

Locations(1)

Beni Suef Hospital

Banī Suwayf, Egypt

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NCT07244770

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