RecruitingNot ApplicableNCT07245134

Virtual Reality Exposure Therapy for Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients

Virtual Reality Exposure Therapy in Patients With Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients

Sponsor

National Institute of Mental Health, Czech Republic

Enrollment

62 participants

Start Date

Nov 15, 2022

Study Type

INTERVENTIONAL

Conditions

Obsessive-Compulsive Disorder Virtual Reality Exposure Therapy Virtual Reality Cognitive Training Cognitive Behavior Therapy

Summary

The aim of this study is to evaluate the efficacy of virtual reality exposure therapy (VRET) as a treatment for obsessive-compulsive disorder (OCD). Participants are randomly assigned to one of the following interventions: a) exposure condition - the group with a standard CBT program enriched with exposure therapy in VR (VRET), b) control condition 1 - the group with a standard CBT program enriched with VR cognitive training aimed at cognitive flexibility or c) control condition 2 - standard CBT program without any additional VR intervention. The treatment effect will be evaluated using pre/post assessments, as well as monitoring adherence to exposure and response prevention assignments.

Eligibility

Min Age: 17 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This trial tests virtual reality exposure therapy (VRET) as a treatment for OCD (obsessive-compulsive disorder) in hospitalized patients in the Czech Republic. In VRET, patients are gradually exposed to anxiety-triggering situations in a safe virtual environment, similar to traditional exposure therapy but using immersive technology. **You may be eligible if...** - You have a confirmed diagnosis of OCD (as defined by DSM-5 or ICD-11) - You are fluent in Czech - You are an inpatient receiving treatment for OCD **You may NOT be eligible if...** - You have other psychiatric, neurological, or serious physical illness (besides OCD) - You have a substance abuse problem - You take certain medications like benzodiazepines (antidepressants and antipsychotics may be acceptable) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALExposure Therapy (Virtual Reality)

Virtual reality scenarios consists of exposures to OCD symptom provoking stimuli and response prevention (e.g. having dirty hands without washing them immediately) with the support of the therapist. The goal of VRET is sufficient reduction in anxiety and acceleration of progress in classical CBT.

BEHAVIORALCognitive flexibility training

Participants play series of various cognitive games previously developed in NIMH aimed at cognitive flexibility. Games are presented using immersive VR (HTC vive headset). The set includes for instance Go/No-go paradigm with a shooting range addressing inhibitory control, Flies - hit a fly game addressing set-shifting and Castle game addressing spatial memory and reversal learning.

BEHAVIORALStandard CBT program without VR interventions

Standart CBT program (performed in all groups). The program involves regular group and individual psychotherapy sessions 5 days per 6 weeks.

Locations(1)

National Institute of Mental Health

Klecany, Czechia

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NCT07245134

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