RecruitingNot ApplicableNCT07245979

Supplementation With Sirtuin Activators in Women With Increased Body Weight

Assessment of the Effect of Sirtuin Activator Supplementation on Cellular, Metabolic and Anthropometric Parameters in Women

Sponsor

Poznan University of Life Sciences

Enrollment

120 participants

Start Date

Oct 8, 2025

Study Type

INTERVENTIONAL

Conditions

Obesity, Overweight

Summary

The goal of this clinical trial is to learn if the six-month supplementation with sirtuin activators can affect metabolism in 40-to-65-year old women with increased body weight. The main questions it aims to answer are: Does sirtuin activators affect lipid and carbohydrate metabolism? Does sirtuin activators affect oxydative stress, immune functions and cell ageing? Researchers will compare sirtuin activators to a placebo (a look-alike substance that contains no drug) to see if drug sirtuin activators works to improve metabolic status. Participants will: Take sirtuin activators or a placebo every day for 6 months. Visit the university once every 3 months for checkups and tests.

Eligibility

Sex: FEMALEMin Age: 40 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is investigating whether taking sirtuin activator supplements for six months can improve metabolism in women aged 40 to 65 with overweight or obesity. Sirtuins are proteins involved in cell aging, and this study is examining whether activating them affects fat and sugar metabolism, oxidative stress, immune function, and cellular aging. Women aged 40 to 65 with a BMI above 25 who are not currently pregnant, breastfeeding, or taking medications for obesity, diabetes, or high cholesterol may be eligible. Participation involves taking either the supplement or a matching placebo daily for 6 months and attending university visits every 3 months for tests and measurements. This summary was prepared to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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