RecruitingPhase 4NCT07247084

A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)

A Phase 4 Multicenter, Randomized, Open-Label, Interventional Study With Pragmatic Elements Investigating the Effectiveness of Tirzepatide Once Weekly Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes in a Real-World Setting


Sponsor

Eli Lilly and Company

Enrollment

3,000 participants

Start Date

Nov 24, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to evaluate tirzepatide within a real-world setting to assess body weight loss and incidence of type 2 diabetes in adults without diabetes who have obesity and at least one weight-related comorbid condition. Participation in the study will last about 260 weeks.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial compares tirzepatide (a newer weight-loss medication) against standard care in adults with obesity to see which approach leads to better weight loss and health improvements. **You may be eligible if...** - Your BMI is between 30 and 34.9 - Your waist-to-height ratio is greater than 0.5 (meaning you carry extra weight around your midsection) - You have at least one weight-related health condition (such as high blood pressure, high cholesterol, or sleep apnea) - You have previously tried to lose weight through diet and exercise changes **You may NOT be eligible if...** - You have any type of diabetes - Your body weight has changed by more than 5 kg (about 11 lbs) in the past 90 days Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTirzepatide

Administered SC

OTHERStandard of Care

Standard of care


Locations(30)

P91604 St John's Medical Centre

Altrincham, United Kingdom

P89008 Ashton Medical Group

Ashton-under-Lyne, United Kingdom

Y02319 SSP Bolton General Practice

Bolton, United Kingdom

P83012 Tower Family Healthcare

Bury, United Kingdom

P91014 Washway Road Medical Centre

Cheshire, United Kingdom

P88007 Cheadle Hulme Medical Group (was Cheadle Hulme Health Centre) (Bridge House)

Cheshire, United Kingdom

Y02790 SSP Bolton Medical Centre

Great Lever, United Kingdom

P89002 The Brooke Surgery

Hyde SK14, United Kingdom

P84035 Bodey Medical Centre

Manchester, United Kingdom

P84630 The Arch Medical Practice

Manchester, United Kingdom

P84678 Didsbury Medical Centre

Manchester, United Kingdom

P84017 Ladybarn Group Practice

Manchester, United Kingdom

P84068 Chorlton Family Practice

Manchester, United Kingdom

P84012 Northenden Group Practice

Manchester, United Kingdom

P86004 Peterloo Medical Centre

Manchester, United Kingdom

P83025 St Gabriels Medical Centre

Manchester, United Kingdom

P87019 Silverdale Medical Practice

Manchester, United Kingdom

P91006 Urmston Group Practice

Manchester, United Kingdom

P92620 SSP Ince Surgery (Lower Ince)

Manchester, United Kingdom

P84034 Barlow Medical Centre

Manchester, United Kingdom

P85010 Woodlands Medical Practice

Oldham, United Kingdom

P85011 CH Medical Practice

Oldham, United Kingdom

P86022 Stonefield Street Surgery

Rochdale, United Kingdom

P91021 Firsway Health Centre

Sale, United Kingdom

P91013 Boundary House Medical Centre

Sale, United Kingdom

P87027 Langworthy Medical Practice

Salford, United Kingdom

P88632 Stockport Medical Group

Stockport, United Kingdom

P87016 The Sides Medical Centre

Swinton, United Kingdom

P87025 The Lakes Medical Practice

Swinton, United Kingdom

Y02322 SSP Leigh Family Practice

Wigen, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07247084


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