RecruitingNCT07247344

Multimodal Phenotyping in Adolescent Inpatient Depression: An Observational Study

Digital Phenotyping and Multimodal Biomarker Discovery for Major Depressive Episodes in Adolescent Inpatients: A Prospective Cohort Study

Sponsor

Jiangsu Province Nanjing Brain Hospital

Enrollment

1,000 participants

Start Date

Mar 1, 2025

Study Type

OBSERVATIONAL

Conditions

Adolescent

Summary

This cohort study involves the dynamic collection of clinical information from adolescent patients with major depressive episodes (including both major depressive disorder and bipolar disorder), encompassing serum parameters, physiological-behavioral signals, neuroimaging data, and neuropsychological scales. The study aims to summarize the comprehensive clinical characteristics of this population, identify new risk factors, and establish multivariate predictive models for treatment response, cognitive and emotional impairments. Furthermore, this research will thoroughly investigate the underlying neural mechanisms linking clinical manifestations and neuroimaging features in major depressive episodes.

Eligibility

Min Age: 10 YearsMax Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This observational study collects detailed clinical, biological, and psychological data from adolescents hospitalized for depression (major depressive disorder) or bipolar disorder. The goal is to better understand what drives these conditions in young people by studying brain imaging, blood markers, sleep patterns, and psychological testing together. **You may be eligible if...** - You are 10 to 20 years old - You have been diagnosed with major depressive disorder or bipolar disorder (meeting DSM-IV criteria) - You are currently hospitalized for psychiatric treatment **You may NOT be eligible if...** - You have a primary diagnosis of a condition other than depression or bipolar disorder - You are unable to participate in the required assessments due to severity of illness - You or your guardian do not consent to participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERdata collection and follow-up

Main measures and data collection methods: 1. Recording of baseline demographic and clinical information of the participants. 2. Multimodal magnetic resonance imaging. 3. Heart rate variability. 4. Electroencephalography. 5. Emotion-related questionnaires. 6. Cognitive tests. 7. Behavioral data collection using wearable devices. 8. Blood samples collection.