The Effect of Colchicine, on Insulin Sensitivity in Individuals With Type 1 Diabetes and Systemic Low-grade Inflammation

This study tests whether colchicine (an anti-inflammatory drug commonly used for gout) can improve insulin sensitivity in people with type 1 diabetes who also have elevated markers of low-grade systemic inflammation. Inflammation may worsen insulin resistance in type 1 diabetes, and colchicine may help reduce it. **You may be eligible if...** - You are 18 to 80 years old with type 1 diabetes (diagnosed for more than 5 years) - Your HbA1c (a measure of long-term blood sugar control) is between 42–75 mmol/mol - You use a continuous glucose monitor (CGM) - Your insulin therapy has been stable (no major changes recently) - You have elevated markers of systemic inflammation (CRP or IL-6 above specific thresholds) **You may NOT be eligible if...** - You have significant kidney or liver disease - You are pregnant or planning to become pregnant - You have a known allergy or intolerance to colchicine - You have had recent major changes to your insulin regimen Talk to your doctor to see if this trial is right for you.