RecruitingNot ApplicableNCT07248709

Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training in Mild Cognitive Impairment

Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training on Executive Functions, Cardiorespiratory and Physical Fitness in Older Adults With Mild Cognitive Impairment

Sponsor

Riphah International University

Enrollment

68 participants

Start Date

Nov 5, 2025

Study Type

INTERVENTIONAL

Conditions

Mild Cognitive Impairment

Summary

This study aims to determine the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on cognitive and physical fitness in community-dwelling adults diagnosed with Mild Cognitive Impairment (MCI). A double-blinded randomized clinical trial will be conducted for ten months at Ruhama Welfare Foundation Society Lahore and Kainat Patient Care and Old Age Home, Lahore. The sample size is calculated through G-power and 68 participants will be recruited through the non-probability convenience sampling technique. Those who meet the inclusion criteria will be randomized into two groups through the online randomizer tool. Both experimental groups will undergo an 8-week intervention, consisting of three sessions per week with alternate-day training of 38 minutes. The HIIT group will perform exercise with each session consisting of four 4-minute intervals at 85-95% of their maximum heart rate, with 3-minute active recovery periods, while the MICT group will engage in continuous exercise for 28 minutes at 70-75% of their maximum heart rate. Assessment will be done at baseline, after the 4th week, 8th week, and follow-up at 12th week.

Eligibility

Min Age: 60 Years

Inclusion Criteria2

older adults who had been diagnosed with MCI according to Peterson's criteria \[Montreal Cognitive Assessment (MoCA) score <26 for those with 12 years or more of education and <25 for those with less than 12 years of education; activity of daily living scale ≤23; no clinical diagnosis of dementia\]
older adults who are physically normal (the six-item Katz Activities of Daily Living Scale should all be evaluated as "independent")

Exclusion Criteria5

Participants who have medical problems or co-morbidities that interdict their participation in the study.
Unable to walk without an assistive device
Diagnosed with neurodegenerative diseases such as Alzheimer's disease
Having regular exercise habits (defined as exercise for ≥150 min per week).
Participating in other ongoing intervention study

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Interventions

OTHERHigh-Intensity Interval Training (HIIT)

The HIIT group will engage in 28 min of alternating high-intensity and low-intensity exercise, where the high-intensity phase will be at 85-90% of maximum heart rate for 4 min, followed by a 3-min recovery period at 50-60% of maximum heart rate, repeated four times on a treadmill or stationary bicycle. (RPE \~16 on Borg scale) Total duration will be 38 minutes including warm up and cool down period.

OTHERModerate-Intensity Continuous Training

The MICT group's training will consist of continuous aerobic exercise for 28 min at 60-70% of maximum heart rate on a treadmill or stationary bicycle. (RPE \~13 on Borg scale) Total duration will be 38 minutes including warm up and cool down period.