Effect of a Short-term Multi-strain Probiotic Supplementation in Endurance Athletes
Effect of a Short-term Multi-strain Probiotic Supplementation on the Exercise- Associated Gastrointestinal Disturbances in Trained Female Athletes Under Controlled Conditions During Professional Training Cycle
Krzysztof Durkalec-Michalski
30 participants
Nov 20, 2025
INTERVENTIONAL
Conditions
Summary
The aim of this project is to evaluate and identify the effect of a short-term 2-week multi-strain probiotic (MPRO) supplementation on the exercise-associated gastrointestinal (GI) symptoms and perturbations in high level female athletes of the Polish national team during strictly controlled conditions of a training camp, based on recommendations for best practices for probiotic (PRO) research in athletes and assessment of EX-associated GI perturbations.
Eligibility
Inclusion Criteria6
- belonging to the national rowing team;
- training experience ≥5 years;
- a currently issued medical certificate confirming
- good health and capacity to practice sports;
- good health without chronic health disorders;
- written informed consent to participate.
Exclusion Criteria11
- injury, any health contraindication or failure to perform exercise procedures;
- gastrointestinal infections, diseases, disorders;
- past history of gastrointestinal surgery, and
- other self-reported gastrointestinal issues;
- reporting symptoms of infection or taking any medication (e.g. antibiotics) for 4 weeks before the study protocol;
- current supplementation of prebiotics,
- probiotics, synbiotics (last 4 weeks);
- current intake of pharmaceutical agents (e.g., nonsteroidal anti-inflammatory drugs, laxatives, antidiarrhea agents, antacids, and/or antiemetics) (last 4 weeks);
- failure to follow the study protocol;
- declared general feeling of being unwell;
- pregnancy or current pregnancy planning.
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Interventions
In the experimental procedure each athlete will be supplemented with a certificated, commercially available MPRO supplement SANPROBI® Barrier (Bifidobacterium lactis W52, Lactobacillus brevis W63, Lactobacillus casei W56, Lactococcus lactis W19, Lactococcus lactis W58, Lactobacillus acidophilus W37, Bifidobacterium bifidum W23, Bifidobacterium lactis W51, Lactobacillus salivarius W24). The supplement will be provided in the capsule form and will be taken twice a day \[4 capsules of MPRO/day (2×10to9 CFU/g, 500 milions CFU/capsule) in two servings/day (2x2 capsules\].
In the control procedure each athlete will be supplemented with a placebo (PLA). The PLA group will receive corn starch mixed with maltodextrins. The PLA will be provided in the capsule form and will be taken twice a day (2x2 capsules/day).
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07252778