RecruitingNot ApplicableNCT07255326

Effect of Omega-3 Fatty Acids on Eye Blood Vessels in Type 1 Diabetes

Role of Omega-3 Fatty Acids in Modulating Retinal Microvascular Changes in Type 1 Diabetes

Sponsor

University of Faisalabad

Enrollment

80 participants

Start Date

Oct 1, 2025

Study Type

INTERVENTIONAL

Conditions

Type 1 Diabetes Diabetic Retinopathy Omega 3 Fatty Acids

Summary

The aim of this clinical trial is to learn if omega-3 fatty acid supplements help maintain healthy blood vessels in the eyes of adults with type 1 diabetes. It will also learn about the safety of omega-3 supplements. The main questions it aims to answer are: Do omega-3 supplements improve the health of retinal blood vessels in adults with type 1 diabetes? Are there any side effects when taking omega-3 supplements? Researchers will compare participants taking omega-3 supplements to a control group (if applicable) to see if the supplements help support retinal blood vessel health. Participants will: Take a daily omega-3 supplement for the duration of the study Attend regular eye exams to monitor changes in the retina Report any side effects or health changes during the study

Eligibility

Min Age: 10 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether omega-3 fatty acid supplements (commonly found in fish oil) can help protect the small blood vessels in the eyes of people with type 1 diabetes who are at risk for diabetic eye disease (diabetic retinopathy). **You may be eligible if...** - You have been diagnosed with type 1 diabetes - You are between 10 and 45 years old - You have had diabetes for at least 2 years - You have mild to moderate diabetic retinopathy (early eye changes from diabetes) or no eye disease yet **You may NOT be eligible if...** - You have another eye disease unrelated to diabetes - You take medications that could affect blood vessels or omega-3 absorption - You have severe diabetic eye complications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTOmega 3 Fish Oil supplements

Arm 1 - Omega-3 Supplement Group: Intervention Type: Dietary Supplement Intervention Name: Omega-3 Fatty Acid Supplement Intervention Description: Participants will take one daily capsule containing 1000 mg of combined EPA and DHA. The supplement is taken orally with food. Eye exams will be performed every three months to monitor retinal blood vessel health. Participants will report any side effects such as mild stomach upset. Arm 2 - Placebo / Control Group: Intervention Type: Placebo Intervention Name: Placebo Capsule Intervention Description: Participants will take a daily capsule that looks identical to the omega-3 supplement but contains no active omega-3 fatty acids. Eye exams will be performed every three months to monitor retinal blood vessel health. Participants will report any health changes.

Locations(1)

Children Hospital Lahore and Ali Fatima Hospital

Lahore, Punjab Province, Pakistan

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NCT07255326

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