RecruitingNCT07255469

Metabolic Fluid Responsiveness in Children

Parameters Associated With Metabolic Response to Volume Expansion in Children Post-operative of Cardiac Surgery

Sponsor

University Hospital, Bordeaux

Enrollment

110 participants

Start Date

Mar 21, 2025

Study Type

OBSERVATIONAL

Conditions

Circulatory Failure / Shock State Fluid Therapy

Summary

The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery. This would allow physicians to identify which patient could benefit the most from fluid expansion, thus avoiding useless and potentially dangerous fluid expansions that could lead to fluid overload. To this end, The investigators will evaluate the diagnostic accuracy of the ratio of central venous to arterial carbon dioxide tension (Pv-aCO2) to arteriovenous oxygen content (CavO2), a simple biological marker of anaerobic metabolism, for the diagnosis of metabolic fluid responsiveness defined as a significant increase in oxygen consumption (VO2) after fluid expansion.

Eligibility

Min Age: 0 DaysMax Age: 15 Years

Plain Language Summary

Simplified for easier understanding

This study looks at how well a child's body responds to receiving extra fluids (fluid resuscitation) during recovery from heart surgery in a pediatric intensive care unit (PICU). Researchers want to find better ways to tell when a child's circulation will actually benefit from additional fluids. **You may be eligible if...** - Your child is 15 years old or younger - Your child is in a pediatric intensive care unit after heart surgery - Your child's doctor has ordered a fluid expansion treatment of 10 ml/kg - Blood gas tests have been ordered before and after the fluid treatment **You may NOT be eligible if...** - Your child did not have cardiac surgery - Your child is not in a pediatric ICU - The required lab tests were not ordered Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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