Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma
Centre Hospitalier Universitaire Dijon
60 participants
Jan 26, 2026
OBSERVATIONAL
Conditions
Summary
Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.
Eligibility
Inclusion Criteria6
- FOR PATIENTS WITH SCLERODERMA :
- Person who has given written consent
- Person with systemic scleroderma
- FOR CONTROL PARTICIPANTS :
- Person who has given written consent
- Person undergoing plastic, cosmetic and reconstructive surgery
Exclusion Criteria13
- FOR PATIENTS WITH SCLERODERMA :
- Person not affiliated to or not benefiting from a social security scheme
- Person subject to a legal protection measure (curatorship, guardianship)
- Person subject to a legal protection measure
- An adult who is incapable or unable to give consent
- Minors
- FOR CONTROLLED PARTICIPANTS :
- Person suffering from a chronic disease or under chronic treatment for autoimmune, inflammatory or dermatological diseases
- Person not affiliated to or not benefiting from a social security scheme
- Person under legal protection (curatorship, guardianship)
- Person subject to a legal protection measure
- An adult who is incapable or unable to give consent
- Minors
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Interventions
* Scleroderma group: skin biopsy for scleroderma patients * Control group: recovery of resected tissue from patients undergoing plastic, reconstructive and aesthetic surgery.
Analysis of samples by RNA sequencing
Locations(1)
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NCT07256418