RecruitingNCT07260071

Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease

Family Study of Early Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease


Sponsor

King's College London

Enrollment

200 participants

Start Date

Aug 15, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this project is to measure the prevalence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and hypertension in the general population of children and young people at risk of ADPKD, using magnetic resonance imaging (MRI) for rapid diagnosis alongside genetic testing. The main question it aims to answer is: What is the prevalence of hypertension in a population sample of adolescents with ADPKD? Participants will have the following measurements performed: * Height and weight. * Blood pressure. * Non-invasive measurement of arterial stiffness. * Cardiac and renal MRI. * Blood sample. * Genetic testing.


Eligibility

Min Age: 12 YearsMax Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This study is monitoring blood pressure in teenagers aged 12–17 who have a parent with autosomal dominant polycystic kidney disease (ADPKD) — an inherited condition that causes cysts to grow on the kidneys — to see whether these children are at early risk of high blood pressure before they develop kidney disease themselves. **You may be eligible if...** - You are between 12 and 17 years old - Your parent has a confirmed clinical diagnosis of ADPKD - You (and your parent if under 16) are willing to consent to genetic testing for ADPKD - You are able to tolerate blood pressure monitoring, MRI, and blood tests **You may NOT be eligible if...** - You are 18 or older at the time of enrollment - You already have a confirmed diagnosis of ADPKD yourself - You are unable to undergo the required assessments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Evelina London Children's Hospital

London, United Kingdom

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NCT07260071