Metabolic Impacts of Ren-Nu: A Dietary Program for Polycystic Kidney Disease

Exclusion Criteria33

• Intolerance or allergy to any of the ingredients in the provided medical food
• Severe or rare underlying health conditions may cause a safety risk when taking the medical food. Those underlying health conditions will be assessed by the enrolling physician and include but are not limited to:
• History of hyperkalemia
• Heart failure
• Liver cirrhosis
• Chronic kidney disease stage 4 or greater, or other renal condition that severely impairs bone mineral homeostasis.
• HIV infection
• Chronic drug or alcohol abuse
• Chronic malabsorption syndrome
• Malignancy (non-melanoma skin cancer exempted)
• Autoimmune disease
• Pregnant, planning to be pregnant, or nursing during the course of the study
• Chronic history of recurrent urinary tract infections (UTI) (≥ 3 UTIs per year)
• Diagnosis of aneurysm
• Indigestion due to hypochlorhydria (low stomach acid)
• Any other condition, that in the opinion of the enrolling physician, makes the subject an unsuitable candidate for the study.
• Current use of any of the following medications or supplements which could affect safety or compliance with this study:
• The medical food, KetoCitra®.
• Urine alkalizing agents such as sodium bicarbonate or potassium citrate
• Citrate treatments
• Immunosuppressive treatment
• Tolvaptan
• Potassium-sparing diuretics
• Somatostatin analogs
• Aluminum-containing supplements or medications such as aluminum antacids (e.g. Maalox) or aluminum-based phosphate binders.
• SGLT2 inhibitors
• Participation in another therapeutic intervention trial.
• Following a highly specialized or extreme diet that is incompatible with the interventional nutrition program (e.g. carnivore, very high protein diet for elite athletes, etc.)
• Food sensitivities or allergies that are incompatible with the interventional nutrition program.
• The subject is already adhering to a form of a ketogenic diet or related fasting regimen.
• Current or past history of disordered eating or feeding behaviors.
• History of gastric bypass.
• Active diagnosis of ulcerative colitis, Irritable Bowel Syndrome, Crohn's, or Gallbladder Disease.