RecruitingPhase 4NCT07263035

Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure


Sponsor

Lakeland Regional Health Systems, Inc.

Enrollment

600 participants

Start Date

Apr 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions it aims to answer are: 1. Does targeting a higher urine sodium goal achieve greater natriuresis and diuresis? 2. Does targeting a higher urine sodium goal reduce frequency of hospital readmissions? 3. Does targeting a higher urine sodium goal reduce hospital length of stay? Researchers will compare natriuresis-guided arms with standard of care to see if targeting higher natriuresis goals improves significantly over current practice. Participants will submit urine samples at routine intervals after being given diuretics to evaluate urine sodium concentration. If urine sodium is low then diuretic dose will be increased.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Furosemide intravenous solution, a drug called Furosemide intravenous solution, and others for people with acute heart failure (ahf), heart failure, and other related conditions. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFurosemide intravenous solution

Diuretics will be titrated to achieve a urine sodium concentration of 50 mmol/L

DRUGFurosemide intravenous solution

Diuretics will be titrated to achieve a urine sodium concentration of 85 mmol/L

DRUGFurosemide intravenous solution

Standard of care


Locations(1)

Lakeland Regional Hospital

Lakeland, Florida, United States

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NCT07263035


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