RecruitingPhase 1NCT07263906

Clinical Study of LILRA6 CAR-T for the Treatment of R/R Acute Myeloid Leukemia

Dose Escalation and Expansion Clinical Study of Targeted LILRA6 CAR-T for the Treatment of Relapsed/Refractory Acute Myeloid Leukemia


Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Enrollment

48 participants

Start Date

Dec 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to evaluate the safety and efficacy of LILRA6-directed chimeric antigen receptor T cells (LILRA6 CAR-T cells) in patients with refractory or relapsed acute myeloid leukemia(AML).


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing LILRA6 CAR-T cell therapy — where a patient's own immune cells are collected, genetically engineered to recognize and destroy leukemia cells, and then given back — for people with acute myeloid leukemia (AML) that has relapsed (come back) or is refractory (not responding to treatment). **You may be eligible if...** - You are between 18 and 75 years old - You have confirmed AML that is refractory (did not achieve remission after two rounds of standard chemotherapy) OR has relapsed after prior treatment - Your cancer was confirmed to relapse within 12 months of remission, OR did not respond to salvage chemotherapy after a later relapse - You are in adequate physical health with functioning organs **You may NOT be eligible if...** - You have AML that responded well to and remains in remission with standard treatment - You have severe heart, liver, kidney, or lung problems - You have active uncontrolled infections or autoimmune disease - You have had prior CAR-T therapy targeting LILRA6 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALAnti-LILRA6 CAR-T cells

lentiviral vector-transducted peripheral blood-derived T cells to express anti-LILRA6 CAR


Locations(1)

The Second Affiliated Hospital,School of Medicine,Zhejiang University

Hangzhou, Zhejiang, China

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NCT07263906


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