RecruitingNot ApplicableNCT07265323

Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition

Effect of Physiologic Insulin Intervention on Insulin Sensitivity and Cognition

Sponsor

Pennington Biomedical Research Center

Enrollment

8 participants

Start Date

Dec 1, 2025

Study Type

INTERVENTIONAL

Conditions

Insulin Sensitivity Alzheimer s Disease Alzheimer Blood Biomarkers

Summary

The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention. The main questions it aims to answer are: Does the intervention improve insulin sensitivity (how the body uses glucose)? Does the intervention improve cognition, measured by the Montreal Cognitive Assessment (MoCA) and the Revised Memory and Behavior Problems Checklist (RMBPC)? What changes occur in brain glucose uptake (FDG-PET)? Participants will: Receive the intervention once a week for 6 months, with each session lasting up to 2 hours Complete cognitive assessments. Adverse events will be assessed throughout the study.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how a method of delivering insulin that more closely mimics what the body does naturally (called physiologic insulin administration) affects insulin sensitivity and thinking/memory (cognition) — particularly in people who may already have some cognitive difficulties. **You may be eligible if...** - You scored below 25 on the Mini Mental State Examination (a standard cognitive screening test), suggesting some degree of cognitive impairment **You may NOT be eligible if...** - You are a child, teenager, or pregnant woman - You are currently in prison or detention - You take daily anti-anxiety medications such as benzodiazepines (e.g., Valium, Xanax) - You have any condition that would make it difficult to participate in the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPhysiological Insulin Intervention

Insulin infusion every five minutes over approximately two hours for six months. Initially infusion will be weekly and then frequency will reduce based on participants' response.