RecruitingNot ApplicableNCT07265336

Excess Base Comparison Between Pregnant Subjects With Severe Preeclampsia vs. Normotensive Pregnant Women

Comparison of Base Excess in Arterial Blood Gases Between Patients With Severe Preeclampsia and Normotensive Pregnant Patients


Sponsor

Saint Thomas Hospital, Panama

Enrollment

100 participants

Start Date

Aug 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals. Researchers will measure these values using an arterial blood gas test before delivery or surgery. This is a prospective cohort study. The researchers will analyze various blood gas parameters, including pH, lactate, and BE, and then correlate the BE values with clinical variables and negative maternal outcomes. The expected outcome is that a abnormal BE values will be linked to a greater severity of preeclampsia. If this association is confirmed, BE could serve as an additional marker for predicting the severity of the condition and may lay the groundwork for future research on diagnostic and therapeutic standards based on blood gas analysis.


Eligibility

Sex: FEMALE

Plain Language Summary

Simplified for easier understanding

This study is measuring a blood marker called excess base in pregnant women with a serious high blood pressure condition called severe preeclampsia, compared to pregnant women with normal blood pressure. The goal is to understand the acid-base balance in preeclampsia. This is an observational study — no new treatments are being tested. **You may be eligible if...** - You are pregnant between 24 and 40 weeks - You have either been diagnosed with severe preeclampsia (cases group) OR you have normal blood pressure during pregnancy (control group) **You may NOT be eligible if...** - You have diabetic ketoacidosis, sepsis, or kidney failure (which can affect acid-base results) - You have persistent diarrhea or vomiting - You have recently received sodium bicarbonate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTArterial Blood gases

Determination of Excess Base in arterial blood gases before delivery / termination of pregnancy


Locations(1)

Saint Thomas Hospital

Panama City, Provincia de Panamá, Panama

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NCT07265336


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