RecruitingPhase 1NCT07270731

A Research Study of a New Medicine, NNC9733-0001, in Healthy Participants and Participants With Type 2 Diabetes

Investigation of Safety, Tolerability, Pharmacokinetic and Pharmacodynamics of Single Administrations of NNC9733-0001 in Healthy Participants and in Participants With Type 2 Diabetes

Sponsor

Novo Nordisk A/S

Enrollment

72 participants

Start Date

Nov 25, 2025

Study Type

INTERVENTIONAL

Conditions

Healthy Volunteer Type 2 Diabetes

Summary

This study is testing a new medicine that might help treat people with type 2 diabetes. The study is conducted to see if the new medicine can lower high sugar levels in the blood. The purpose of the study is to see if the new study medicine is safe and how well is tolerated by the body. There will be two groups of partici-pants in this study: healthy participants and participants with type 2 diabetes. Participant will either get study medicine (NNC9733-0001) or placebo (a treatment that has no active medicine in it). Which treatment the participant gets is decided by chance. Which dose (strength) the participant get is determined by when participant enter the study. Participant will get one dose which will be injected into the area around abdomen (belly) by the medical staff. The number of injections (up to 4 injections) will depend on the group the participant is assigned to. Larger doses require multiple injections. The study will last for about 40 weeks (10 months).

Eligibility

Min Age: 18 YearsMax Age: 64 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a brand-new experimental medicine called NNC9733-0001 in healthy adults and in people with type 2 diabetes. Researchers want to understand how the body processes and responds to this drug, including whether it is safe and how it affects blood sugar levels. **You may be eligible if...** - You are an adult (age requirements vary by study part) - You are male, or a female who cannot become pregnant - For the diabetes group: you have been diagnosed with type 2 diabetes - You are generally in stable health **You may NOT be eligible if...** - You are a woman who could become pregnant - You have significant heart, liver, kidney, or other serious medical conditions - You have used insulin or certain other diabetes medications recently - You smoke heavily or have a high BMI that falls outside the study range Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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