Real-world Outcomes of Peripheral T-cell Lymphoma: A Multicenter Retrospective and Prospective Cohort Study
A Multicenter, Non-interventional, Two-cohort Study to Describe Real-world Treatment Patterns and Outcomes in Patients With Peripheral T-cell Lymphoma
Fudan University
3,000 participants
Nov 15, 2025
OBSERVATIONAL
Conditions
Summary
This study aims to characterize the epidemiology, clinicopathologic features, and survival outcomes of Chinese patients with PTCL; to develop and validate prognostic models to this population; to compare the real-world effectiveness and safety of alternative therapeutic strategies; to elucidate molecular mechanisms underlying treatment resistance and relapse; to identify actionable targets and predictive biomarkers.
Eligibility
Inclusion Criteria4
- Age ≥18 years, with a histopathologic diagnosis of PTCL (any subtype per WHO 2016 classification of hematolymphoid neoplasms).
- Cohort A: Patients diagnosed and treated at participating centers between 2010 and 2024.
- Cohort B: Patients newly diagnosed from October 2025 onward.
- Availability of basic diagnostic and treatment records .
Exclusion Criteria3
- Indeterminate diagnosis or missing pathology report.
- Patients diagnosed at an outside institution who did not receive their primary treatment and follow-up at a participating center.
- Diagnoses of NK/T-cell lymphoma or primary cutaneous T-cell lymphomas.
Interventions
Observational
Locations(1)
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NCT07270861