RecruitingPhase 2NCT07273838

Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome

Sodium-Glucose Cotransporter-2 Inhibitor for Amelioration of Acute Cardiorenal Syndrome: A Randomized Controlled Trial


Sponsor

Yale University

Enrollment

130 participants

Start Date

Mar 5, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The overall objective of this study is to determine whether the addition of SGLT2 inhibitors to usual care in hospitalized patients with heart failure associated acute kidney injury is safe and efficacious. Investigators will assess if SGLT2 inhibition improves a composite cardio-renal outcome (mortality, dialysis, AKI progression, decongestion metrics, heart failure symptoms). Secondary objectives of this study are to compare individual components of the composite outcome as well as changes in biomarkers of kidney injury, inflammation, repair and oxidative stress between those exposed to the SGLT2 inhibitor vs placebo.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether an SGLT2 inhibitor — a type of pill that lowers blood sugar and helps the kidneys and heart — can help patients with acute cardiorenal syndrome, a condition where both the heart and kidneys are failing at the same time. **You may be eligible if...** - You are between 18 and 85 years old - You have heart failure (either reduced or preserved pumping function) - You are experiencing a worsening of heart failure symptoms - You are able to take oral medication - You are willing to follow the study schedule **You may NOT be eligible if...** - You have type 1 diabetes - Your kidney function is severely impaired (very low eGFR) - You are in cardiogenic shock (heart failing so severely you need emergency intervention) - You are already on an SGLT2 inhibitor - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDapagliflozin 10mg Tab

Administration of 10mg oral dapagliflozin once daily for 14 days (or until discharge).

DRUGPlacebo

Administration of placebo comparator once daily for 14 days (or until discharge).


Locations(2)

Yale New Haven Hospital-St. Raphael Campus

New Haven, Connecticut, United States

Yale New Haven Hospital

New Haven, Connecticut, United States

View Full Details on ClinicalTrials.gov

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NCT07273838


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