RecruitingPhase 2NCT07279558

Cannabidiol and Alcohol Use Disorder Phenotypes

Effects of Full-spectrum Cannabidiol on Alcohol Consumption and Alcohol Use Disorder Phenotypes: Implications for Precision Medicine

Sponsor

University of Colorado, Denver

Enrollment

150 participants

Start Date

Mar 31, 2026

Study Type

INTERVENTIONAL

Conditions

Alcohol Use Disorder

Summary

The goal of this study is to learn how CBD affects drinking in people who drink alcohol regularly. Researchers want to see if CBD can help people drink less and reduce problems related to alcohol use.

Eligibility

Min Age: 21 YearsMax Age: 65 Years

Inclusion Criteria4

Age 21-65
Have used CBD and cannabis at least once in the last year
Regularly drink alcohol
Able to provide informed consent and attend in-person study visits

Exclusion Criteria5

Current use of medications known to have major interaction with Epidiolex, Marinol, or alcohol
Current use of antiepileptic medication or any psychotropic medication besides antidepressants
Pregnant, nursing, or planning a pregnancy
Medical conditions that contraindicates the use of CBD or alcohol
Current medical conditions that may require intensive care during the study period

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Interventions

DRUGFull-Spectrum Cannabidiol (CBD)

Dose: Approximately 200mg of full-spectrum CBD (\<0.3% THC) Active Ingredients: Full spectrum hemp extract Other Ingredients: Hemp seed oil, glycerin, gelatine.

DRUGBroad-Spectrum Cannabidiol (CBD)

Dose: Approximately 200mg of broad-spectrum CBD, (0% THC) Active Ingredients: Broad spectrum hemp extract Other Ingredients: Hemp seed oil, glycerin, gelatine.

DRUGPlacebo

Active Ingredients: N/A Other Ingredients: Hemp seed oil, glycerin, gelatine.