RecruitingNCT07281040

Preparatory Work for a Trial of Adjuncts to Diuretic Treatment in Patients Hospitalised With Heart Failure: Addressing Uncertainties and Building Consensus

Preparatory Work for a Multi-arm, Multi-stage Trial of Adjunctive Treatments in Patients Hospitalised With Heart Failure (Pre-MAMMOTH-HF)

Sponsor

Hull University Teaching Hospitals NHS Trust

Enrollment

10 participants

Start Date

Jul 2, 2025

Study Type

OBSERVATIONAL

Conditions

Heart Failure

Summary

Aims and Objectives 1. Choose which adjunctive therapies, at what dose, and for how long 2. Choose the dose(s) of IV furosemide to be used as the comparator 3. Choose primary and secondary outcomes 4. Estimate recruitment and engage sites for a future trial Work package 2a methods overview 1. An online survey of clinicians (doctors, nurses and pharmacists) assessing potential ability to recruit and the acceptability of each adjunct and willingness to support a trial. 2. Evidence generated (survey and reviews) will be considered by an expert panel (N=20-25) including expert clinicians and allied health professionals who care for people with HF using a modified Delphi approach. The panel will make recommendations on all aspects of the trial design. 3. A patient and carer panel of people with a recent hospitalisation (\<6 months) for HF will provide recommendations on trial endpoints. The patient-and-carer advisory group (PCAG) will also input into these discussions.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a preparatory study — it uses online group discussions rather than medical treatment — to gather input from patients and caregivers about uncertainties in treating fluid buildup (congestion) in hospitalized heart failure patients, to help design a future clinical trial. **You may be eligible if...** - You were hospitalized for heart failure in the past 6 months, OR you are a carer for someone who was - You are able to participate in online group discussions in English **You may NOT be eligible if...** - You are unable to participate in online group discussions in English Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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