RecruitingNCT07284082

The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women


Sponsor

University of California, San Francisco

Enrollment

90 participants

Start Date

Apr 17, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap. The goal of this observational study is to address this knowledge gap by looking at the role of menopause on cardiovascular disease risk factors such as insulin resistance, hypertension, hyperlipidemia, and carotid atherosclerosis using previously collected data. The investigators will look at underlying causes for cardiovascular diseases worsening in menopausal women with HIV by looking at the role of increased inflammation in the body and whether this is altered by weight. The investigators achieve this by enrolling participants who are willing to undergo a whole body MRI.


Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria1

  • non-pregnant women with HIV (approximately 30 in each menopausal phase) from the San Francisco MWCCS site.

Exclusion Criteria4

  • Women who are not virally suppressed (HIV RNA >200 copies/mL)
  • Women who are not on antiretroviral therapy
  • Women who have a history of hysterectomy or oophorectomy
  • Women who are receiving treatment for active cancer or tuberculosis

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Interventions

DIAGNOSTIC_TESTWhole body MRI

Whole body MRI will be performed as part of a study protocol


Locations(1)

University of California, San Francisco

San Francisco, California, United States

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NCT07284082


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