Study to Evaluate the Use of Surgical Gloves for the Prevention of Oxaliplatin-Induced Peripheral Neuropathy

This trial is testing whether wearing surgical gloves during chemotherapy infusions can prevent nerve damage in the hands and feet — a painful and common side effect called peripheral neuropathy — in people receiving oxaliplatin chemotherapy for colon cancer. **You may be eligible if...** - You are 18 or older with colon cancer (high-risk stage III or stage IV) - You are being treated with oxaliplatin-based chemotherapy (either for localized or metastatic disease) - Your functional status is good (ECOG 0–1, meaning you can carry out daily activities independently) - You have provided written informed consent **You may NOT be eligible if...** - You already have nerve damage in your hands or feet (pre-existing neuropathy) - You have uncontrolled diabetes, which can also cause nerve problems - You have a known allergy to surgical gloves - You have previously been treated with paclitaxel, docetaxel, or oxaliplatin chemotherapy Talk to your doctor to see if this trial is right for you.