RecruitingNot ApplicableNCT07285356

Study to Evaluate the Use of Surgical Gloves for the Prevention of Oxaliplatin-Induced Peripheral Neuropathy

GLOX-PEN: Phase II Clinical Trial to Evaluate the Use of Surgical Gloves for the Prevention of Oxaliplatin-Induced Peripheral Neuropathy

Sponsor

AC Camargo Cancer Center

Enrollment

84 participants

Start Date

Oct 6, 2025

Study Type

INTERVENTIONAL

Conditions

Colon Cancer Oxaliplatin-induced Peripheral Neuropathy

Summary

The primary objective of this randomized clinical trial is to assess whether the use of surgical gloves during treatment can prevent the occurrence of oxaliplatin-induced peripheral neuropathy.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Patients aged 18 years or older who have provided written informed consent.
Colon adenocarcinoma with high-risk stage III (pT4pN2) or stage IV.
Oxaliplatin-based treatment in the context of localized or metastatic disease.
Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.

Exclusion Criteria4

Pre-existing neuropathy.
Uncontrolled diabetes.
known glove allergies.
Prior treatment with paclitaxel, docetaxel or oxaliplatin.

Interventions

DEVICESurgical Gloves

During each chemotherapy cycle, patients in the experimental group will wear compressive surgical gloves (one size smaller than recommended based on palmar surface measurement) on both hands, which will be put on 30 minutes before the infusion and remain in place until 30 minutes after the end of the chemotherapy infusion.