A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Melanoma

This trial is studying lifileucel — a treatment made from your own tumor-fighting immune cells (called tumor-infiltrating lymphocytes, or TILs) that are grown in a lab and infused back — for people with advanced melanoma that has not responded to immunotherapy. **You may be eligible if...** - You are an adult with advanced (Stage IIIC, IIID, or IV) unresectable or metastatic melanoma - Your melanoma has continued to grow or spread during or after treatment with an anti-PD-(L)1 drug - Your performance level is good (ECOG 0 or 1) with life expectancy over 6 months - You have at least one tumor that can be surgically removed to make the TIL therapy - If your tumor has a BRAF V600 mutation, you may have had one additional prior BRAF/MEK inhibitor treatment **You may NOT be eligible if...** - Your melanoma has not been treated with immunotherapy yet - You cannot have surgery to collect tumor tissue - Your performance level or organ function is too poor for this intensive treatment - You have active brain metastases that are untreated Talk to your doctor to see if this trial is right for you.