RecruitingPhase 1NCT07290036

A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults

An Open-label, Randomized, Parallel-group, Noninferiority Study to Evaluate the Pharmacokinetics of Bimekizumab Administered Intravenously or as a Subcutaneous Injection in Participants With Active Psoriatic Arthritis and/or Active Axial Spondyloarthritis

Sponsor

UCB Biopharma SRL

Enrollment

392 participants

Start Date

Dec 10, 2025

Study Type

INTERVENTIONAL

Conditions

Psoriatic Arthritis Axial Spondyloarthritis

Summary

To demonstrate that bimekizumab administered intravenously is noninferior to subcutaneous administration.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Bimekizumab regimen 1 iv, a drug called Bimekizumab regimen 2 iv, and others for people with axial spondyloarthritis and psoriatic arthritis. The study is currently recruiting participants at 61 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGBimekizumab regimen 1 iv

Participants will receive bimekizumab (BKZ) at pre-specified time points.

DRUGBimekizumab regimen 2 iv

Participants will receive bimekizumab (BKZ) at pre-specified time points.

DRUGBimekizumab regimen 3 sc

Participants will receive bimekizumab (BKZ) at pre-specified time points.

Locations(63)

Pa0019 114

Peoria, Arizona, United States

Pa0019 127

Apple Valley, California, United States

Pa0019 111

Covina, California, United States

Pa0019 119

Fullerton, California, United States

Pa0019 117

Riverside, California, United States

Pa0019 125

San Leandro, California, United States

Pa0019 126

Temecula, California, United States

Pa0019 141

Upland, California, United States

Pa0019 120

Whittier, California, United States

Pa0019 128

Whittier, California, United States

Pa0019 123

Fort Collins, Colorado, United States

Pa0019 143

Ormond Beach, Florida, United States

Pa0019 113

South Miami, Florida, United States

Pa0019 133

Zephyrhills, Florida, United States

Pa0019 132

Chicago, Illinois, United States

Pa0019 134

Lansing, Michigan, United States

Pa0019 140

West Long Branch, New Jersey, United States

Pa0019 131

Albuquerque, New Mexico, United States

Pa0019 144

Vandalia, Ohio, United States

Pa0019 115

Duncansville, Pennsylvania, United States

Pa0019 142

Rock Hill, South Carolina, United States

Pa0019 116

Jackson, Tennessee, United States

Pa0019 138

Murfreesboro, Tennessee, United States

Pa0019 129

Baytown, Texas, United States

Pa0019 136

Colleyville, Texas, United States

Pa0019 135

Mesquite, Texas, United States

Pa0019 124

Plano, Texas, United States

Pa0019 121

Bellevue, Washington, United States

Pa0019 145

Spokane, Washington, United States

Pa0019 130

Beckley, West Virginia, United States

Pa0019 204

Lovech, Bulgaria

Pa0019 205

Pleven, Bulgaria

Pa0019 201

Plovdiv, Bulgaria

Pa0019 202

Plovdiv, Bulgaria

Pa0019 203

Plovdiv, Bulgaria

Pa0019 705

Brno, Czechia

Pa0019 703

Hlučín, Czechia

Pa0019 704

Ostrava, Czechia

Pa0019 702

Uherské Hradiště, Czechia

Pa0019 305

Berlin, Germany

Pa0019 301

Hamburg, Germany

Pa0019 302

Ratingen, Germany

Pa0019 306

Wetzlar, Germany

Pa0019 407

Bialystok, Poland

Pa0019 418

Bialystok, Poland

Pa0019 404

Bytom, Poland

Pa0019 401

Elblag, Poland

Pa0019 412

Krakow, Poland

Pa0019 402

Lodz, Poland

Pa0019 410

Lublin, Poland

Pa0019 413

Nowa Sól, Poland

Pa0019 417

Olsztyn, Poland

Pa0019 406

Poznan, Poland

Pa0019 408

Poznan, Poland

Pa0019 411

Poznan, Poland

Pa0019 415

Płońsk, Poland

Pa0019 416

Torun, Poland

Pa0019 405

Warsaw, Poland

Pa0019 409

Warsaw, Poland

Pa0019 414

Warsaw, Poland

Pa0019 420

Wroclaw, Poland

Pa0019 601

Košice, Slovakia

Pa0019 603

Piešťany, Slovakia

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07290036

Related Trials

A Clinical Trial of TQH3906 Capsules in the Treatment of Active Psoriatic Arthritis

NCT0740603544 locations

Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders

NCT071805371 location

Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in Autoimmune Rheumatic Diseases

NCT070879122 locations

A Study to Assess the Concentration of Bimekizumab in Mature Breast Milk From Mothers Receiving Treatment With Bimzelx® (Bimekizumab)

NCT0688819314 locations

HLA B Leader in Patients With Psoriatic Arthritis

NCT077188151 location