A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for High-Grade Appendiceal and Colorectal Adenocarcinoma With Peritoneal Metastasis

This study evaluates a drug sensitivity testing approach — analyzing actual tumor samples from surgery to determine which chemotherapy drugs work best — to guide personalized treatment for patients with peritoneal metastases (cancer that has spread to the lining of the abdomen). **You may be eligible if...** - You have confirmed cancer that has spread to the peritoneal lining (abdominal lining), from appendix, colorectal, or related sources - You have limited or stable spread to other parts of the body - Your disease is considered unresectable (cannot be fully removed by surgery) or has a high peritoneal spread score - You are in adequate health with expected survival of more than 3 months **You may NOT be eligible if...** - Your cancer has spread extensively beyond the abdomen in ways that cannot be treated - Your organ function does not meet the minimum requirements for the procedure Talk to your doctor to see if this trial is right for you.