Ketamine and Propofol NeuroImaging
Keith M Vogt
60 participants
Apr 30, 2026
INTERVENTIONAL
Conditions
Summary
This is a multi-visit which will collect MRI (pictures of the brain) and EEG (brain waves) data to determine changes in brain connectivity and brain activity for memory formation and pain perception while receiving the commonly-used anesthetic agents ketamine and propofol, both alone and in combination.
Eligibility
Inclusion Criteria1
- Adults 18-59 years of age, who:
Exclusion Criteria19
- have a valid email address and valid phone number throughout the study
- free from any non-MRI compatible implants
- are pregnant or attempting to conceive
- body mass index (BMI) \> 35
- significant memory impairment or hearing loss
- sleep apnea
- chronic pain or frequently taking pain medication
- chronic medical conditions requiring treatment (hypertension, diabetes, high cholesterol)
- neurologic disease, including seizures and tremor
- psychiatric diagnoses, including anxiety, depression, panic, or PTSD
- a history of any of these medical conditions: abnormal heartbeats (cardiac conduction abnormality or arrhythmia), liver or kidney disease, or significant lung disease
- severe claustrophobia or intolerance of an MRI
- have metal implants or non-removable metal piercings
- having a history of adverse reaction to ketamine or propofol
- daily alcohol or heavy alcohol use; history of alcohol abuse
- current daily smoker
- regular or recent marijuana use (including prescribed/medical marijuana)
- illicit drug use, i.e., street drugs
- regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids
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Interventions
Subjects will receive an intravenous infusion of this drug, during portions of the study.
Subjects will receive an intravenous infusion of this drug, during portions of the study.
Experimental acute pain stimulus will be delivered using a nerve stimulator. These painful shocks will be paired with specific experimental events.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07294092