RecruitingEarly Phase 1NCT07294092

Ketamine and Propofol NeuroImaging

Sponsor

Keith M Vogt

Enrollment

60 participants

Start Date

Apr 10, 2026

Study Type

INTERVENTIONAL

Conditions

Pain Anesthesia

Summary

This is a multi-visit which will collect MRI (pictures of the brain) and EEG (brain waves) data to determine changes in brain connectivity and brain activity for memory formation and pain perception while receiving the commonly-used anesthetic agents ketamine and propofol, both alone and in combination.

Eligibility

Min Age: 18 YearsMax Age: 59 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Ketamine, a medical device called Peripheral Nerve Stimulation, and others for people with anesthesia and pain. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 59 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPropofol

Subjects will receive an intravenous infusion of this drug, during portions of the study.

DRUGKetamine

Subjects will receive an intravenous infusion of this drug, during portions of the study.

DEVICEPeripheral Nerve Stimulation

Experimental acute pain stimulus will be delivered using a nerve stimulator. These painful shocks will be paired with specific experimental events.

Locations(1)

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

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NCT07294092

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