RecruitingPhase 4NCT07294209

Low-Dose Tenecteplase for Acute Ischemic Stroke Treatment in Aging Patients

Efficacy and Safety of Low-Dose Tenecteplase for Acute Ischemic Stroke Treatment in Aging Patients: A Prospective, Multicenter, Randomized Controlled Study

Sponsor

Southwest Hospital, China

Enrollment

798 participants

Start Date

Dec 19, 2025

Study Type

INTERVENTIONAL

Conditions

Acute Ischemic Stroke Patients

Summary

The DATE-AGING study is a prospective, multicenter, randomized controlled trial investigating low-dose tenecteplase in elderly patients with acute ischemic stroke. Its primary objective is to evaluate the safety and efficacy of low-dose tenecteplase in elderly patients within 4.5 hours of acute ischemic stroke onset.

Eligibility

Min Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called low-dose tenecteplase intravenous thrombolysis and a drug called standard-dose tenecteplase intravenous thrombolysis for people with acute ischemic stroke patients. The study is currently recruiting participants at 51 locations. People eligible for this study include aged 70 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGlow-dose tenecteplase intravenous thrombolysis

Subjects will be randomized to low-dose group or standard-dose group in a 1:1 ratio. Patients in the low-dose group received tenecteplase (0.175 mg/kg) for intravenous thrombolysis. The upper dose limit is set to 17.5 mg/patient.

DRUGstandard-dose tenecteplase intravenous thrombolysis

Subjects will be randomized to low-dose group or standard-dose group in a 1:1 ratio. Patients in the standard-dose group received tenecteplase (0.25 mg/kg) for intravenous thrombolysis. The upper dose limit is set to 25 mg/patient.

Locations(51)

Southwest Hospital, Chongqing, China

Chongqing, Chongqing Municipality, China

Wuchang People's Hospital

Harbin, Heilongjiang, China

Shenqiu County People's Hospital

Zhoukou, Henan, China

Anshan Changda Hospital

Anshan, China

Anyang People's Hospital

Anyang, China

Huaxian People's Hospital of Henan

Anyang, China

Baoshan People's Hospital

Baoshan, China

People's Hospital of Zhijin County

Bijie, China

Bishan Hospital

Chongqing, China

Chongqing Emergency Medical Center

Chongqing, China

Chongqing University Fuling Hospital

Chongqing, China

Chongqing University Jiangjin Hospital

Chongqing, China

Chongqing University Three Gorges Hospital

Chongqing, China

Dianjiang People's Hospital OF Chongqing

Chongqing, China

People's Hospital Of Xiushan County

Chongqing, China

The People's Hospital of Dazu Chongqing

Chongqing, China

The People's Hospital of HeChuan, Chongqing

Chongqing, China

The People's Hospital of Rongchang Chongqing

Chongqing, China

The People's Hospital of Tongnan District Chongqing City

Chongqing, China

The Seventh People's Hospital of Chongqing

Chongqing, China

Tongliang Hospital

Chongqing, China

Yunyang County People's Hospital

Chongqing, China

Dali Bai Autonomous Prefecture People's Hospital

Dali, China

Dazhou Central Hospital

Dazhou, China

The People's Hospital of Zhongjiang

Deyang, China

Guang an People's Hospital

Guang’an, China

Guizhou Provincial People's Hospital

Guiyang, China

The Second People's Hospital of Guiyang（Guiyang Jinyang Hospital）

Guiyang, China

The First Affiliated Hospital of Harbin Medical University

Ha’erbin, China

Xunxian People's Hospital

Hebi, China

Heyuan People's Hospital

Heyuan, China

Qichun People's Hosiptal

Huanggang, China

The People's Hospital Of Jianyang City

Jianyang, China

Laixi People's Hospital

Laixi, China

Leshan Geriatric Specialized Hospital

Leshan, China

People's Hospital of Leshan

Leshan, China

Luoyang Mengjin People's Hospital

Luoyang, China

Nanbu People's Hospital

Nanchong, China

Puyang People's Hospital

Pujiang, China

The People's Hospital of Nan Le Xian

Pujiang, China

People's Hospital of Ningling County

Shangqiu, China

The First People's Hospital of Shangqiu

Shangqiu, China

The First People ' S Hospital of Shao Yang

Shaoyang, China

The People's Hospital of Gaocheng

Shijiazhuang, China

Wuhan Puren Hospital

Wuhan, China

Xiangyang NO.1 People's Hospital

Xiangyang, China

The second people's hospital of Yibin

Yibin, China

Zhumadian Central Hospital

Zhumadian, China

Zhuzhou Central Hospital

Zhuzhou, China

Zigong Third People's Hospital

Zigong, China

Ziyang Central Hospital

Ziyang, China

View Full Details on ClinicalTrials.gov

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NCT07294209

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