Impact of Lifestyle Interventions on Cognitive Decline in Non-alcoholic Fatty Liver Disease
Impact of Lifestyle Interventions on Cognitive Decline in NAFLD: A Randomized Controlled Trial of Liver Fibrosis, Hormonal Imbalance, and Inflammatory Markers
Khyber Medical University Peshawar
45 participants
Oct 1, 2025
INTERVENTIONAL
Conditions
Summary
This study investigates whether a structured lifestyle program can help improve thinking skills and liver health in adults with Non-Alcoholic Fatty Liver Disease (NAFLD). We are enrolling 45 participants, aged 18-42, who will be randomly assigned to one of three groups for six months: one receiving general health advice, a second following a supervised Mediterranean diet plan, and a third combining the same diet with a regular walking program. The main goal is to see if these diet and exercise interventions can lead to better scores on memory and reasoning tests, reduce liver stiffness measured by a painless scan (FibroScan), and improve related blood markers of inflammation and hormone balance.
Eligibility
Inclusion Criteria4
- Age 18 to 42 years.
- Diagnosed with fatty liver (NAFLD) via imaging (e.g., ultrasound).
- Liver fibrosis assessed and staged via FibroScan and the FIB-4 index.
- Literate (to consent and complete cognitive assessments/questionnaires).
Exclusion Criteria5
- History of alcohol intake >20g/day.
- Chronic viral hepatitis B or C.
- Major neuropsychiatric illnesses.
- Pregnancy or breastfeeding.
- Chronic illnesses including Diabetes Mellitus and thyroid dysfunction.
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Interventions
A culturally adapted, structured dietary plan based on the Mediterranean diet principles, delivered through individual dietitian counseling, provision of weekly meal plans, and ongoing compliance support (food diaries, recalls, monthly check-ins).
This intervention consists of providing standardized, non-structured verbal and written information on the principles of a balanced diet and the benefits of regular physical activity, as per routine clinical practice. It serves as the active comparator representing minimal intervention.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07294963