RecruitingNot ApplicableNCT07296744

Pivotal Study of the SUpira System in Patients Undergoing High-Risk Percutaneous COronaRy InTervention (HRPCI)

Pivotal Randomized Study of the SUpira System in Patients Undergoing High-Risk Percutaneous COronaRy InTervention (HRPCI)


Sponsor

Supira Medical

Enrollment

358 participants

Start Date

May 11, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The objective of this study is to assess the safety and efficacy of the Supira System in providing temporary cardiovascular hemodynamic support in patients undergoing HRPCI. Eligible patients will be randomized to undergo HRPCI with either the Supira System (investigational device) or the commercially available Impella systems (comparator device).


Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Impella and a medical device called The Supira System for people with coronary artery disease, high risk percutaneous coronary intervention, and other related conditions. The study is currently recruiting participants at 14 locations. People eligible for this study include aged 18 Years to 90 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEThe Supira System

The Supira System is a temporary (≤ 4 hours) ventricular support device indicated for use during elective or urgent HRPCI performed in hemodynamically stable patients with severe coronary artery disease when a heart team has determined HRPCI is the appropriate therapeutic option.

DEVICEImpella

The current commercially available Impella CP with SmartAssist Catheter is indicated for providing temporary (≤ 6 hours) ventricular support during elective or urgent high risk percutaneous coronary i


Locations(24)

Loma Linda University Medical Center

Loma Linda, California, United States

UC Davis

Sacramento, California, United States

Los Robles Regional Medical Center

Thousand Oaks, California, United States

Piedmont Heart Institute

Atlanta, Georgia, United States

Emory University Hospital

Atlanta, Georgia, United States

Northside Hospital

Lawrenceville, Georgia, United States

Northwestern University

Chicago, Illinois, United States

Henry Ford Health / St. John Hospital

Detroit, Michigan, United States

CentraCare

Saint Cloud, Minnesota, United States

Washington University in St. Louis

St Louis, Missouri, United States

Virtua Health

Camden, New Jersey, United States

University of Buffalo (Buffalo General)

Buffalo, New York, United States

Cuimc/Nyph

New York, New York, United States

Montefiore Medical Center

The Bronx, New York, United States

Mission Health

Asheville, North Carolina, United States

OhioHealth

Columbus, Ohio, United States

Oklahoma Heart Hillcrest Medical

Tulsa, Oklahoma, United States

Providence

Portland, Oregon, United States

OHSU

Portland, Oregon, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Wellspan York Hospital

York, Pennsylvania, United States

Prisma Health

Columbia, South Carolina, United States

Baylor Scott & White The Heart Hospital

Plano, Texas, United States

Intermountain Health

Murray, Utah, United States

View Full Details on ClinicalTrials.gov

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NCT07296744


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