RecruitingNCT07298720

Assessing Fluid-responsiveness Using Non-invasive Hybrid Diffuse Optics on Peripheral Muscle

Sponsor

Corporacion Parc Tauli

Enrollment

200 participants

Start Date

Jan 7, 2025

Study Type

OBSERVATIONAL

Conditions

Critical Illness

Summary

Proof-of-concept observational study including ICU patients undergoing a PLR maneuver. Local microvasculature will be assessed with the hDOS platform on the brachioradialis muscle, deriving the microvascular blood flow index (BFI) and tissue oxygen saturation (StO2). CO will be assessed via an invasive hemodynamic monitor based on pulse waveform analysis through the patient's arterial line. The correlation over time between CO and microvascular parameters, and the ability of microvascular variables for predicting a positive CO response (increase \> 10%) will be assessed.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

Invasive blood pressure monitoring through an arterial line

Exclusion Criteria3

Patients with suspected pregnancy
Intra-abdominal hypertension
Elevated intracranial pressure

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Interventions

OTHERPassive Leg Raising maneuver

The PLR will be performed using automatic bed adjustment: Starting from a semi-recumbent position, the lower limbs will be elevated to a 45° angle while the trunk will be moved from semi-recumbent to supine. After three minutes, subjects will be returned to the initial semi-recumbent position.