Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients
Proteomic Analysis of Exhaled Breath Condensate in Mechanically Ventilated Intensive Care Patients
The Institute of Molecular and Translational Medicine, Czech Republic
200 participants
Mar 1, 2026
OBSERVATIONAL
Conditions
Summary
Mechanically ventilated intensive care patients will be sampled for a small amount of exhaled breath condensate from the ventilator circuit and for venous blood. Proteomic analysis of the exhaled breath condensate will be performed using mass spectrometry and in the blood sample, corresponding changes in the DNA, RNA, proteins, and metabolites will be studied. Resulting profiles will be correlated with routinely monitored parameters in order to identify patterns corresponding to various pathologies in order to enable their early detection.
Eligibility
Inclusion Criteria1
- Intensive care setting Mechanical ventilation Ventilator/ventilator circuit technically suitable for sampling of exhaled breath condensate
Exclusion Criteria1
- Mechanical ventilation challenging to the extent that the insertion of the sampling kit into the ventilator circuit would substantially increase the risk for respiratory deterioration
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Interventions
Mechanically ventilated intensive care patients will be sampled for exhaled breath condensate from the ventilator circuit.
Locations(2)
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NCT06189924