RecruitingPhase 1NCT07300280

A Clinical Trial of Enlicitide and Rosuvastatin in Healthy Adults (MK-0616-039)

A Clinical Study to Evaluate the Relative Bioavailability of FDC Tablets Containing Enlicitide and Rosuvastatin, Compared to Enlicitide and Rosuvastatin Administered Concomitantly as Single Entities, in Healthy Adult Participants


Sponsor

Merck Sharp & Dohme LLC

Enrollment

60 participants

Start Date

Dec 29, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This goal of this trial is to learn about two medicines, enlicitide and rosuvastatin, in healthy people. Researchers will compare the amounts of enlicitide and rosuvastatin in a person's body over time, when they are given as separate medicines and when they are combined into one tablet.


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Inclusion Criteria2

  • Is medically healthy with no clinically significant medical history
  • Is a non-smoker who has not used nicotine- and tobacco-containing products for at least 3 months prior to study entry

Exclusion Criteria2

  • Is unable to refrain from or anticipates the use of any drugs, including prescription and non-prescription medications, herbal remedies, or vitamin supplements beginning 14 days prior to study entry
  • Is a female participant of childbearing potential

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Interventions

DRUGMK-0616A

Enlicitide/rosuvastatin fixed dose combination (FDC) or enlicitide/rosuvastatin FDC formulation B oral tablets

DRUGEnlicitide

Oral tablet

DRUGRosuvastatin

Oral tablet


Locations(1)

Celerion ( Site 0001)

Tempe, Arizona, United States

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NCT07300280


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