Postoperative Hypoxemia Increases the Risk of Anastomotic Leak After Radical Esophagectomy
Sun Yat-sen University
2,500 participants
Jan 1, 2021
OBSERVATIONAL
Conditions
Summary
This study aims to determine whether postoperative hypoxia (arterial partial pressure of oxygen (PaO₂)\<80 mmHg) is an independent risk factor for anastomotic leakage after esophagectomy. The investigators conducted a retrospective analysis of cases from their center over the past five years, stratifying patients into Low Pa0₂ Group and Normal Pa0₂ Group based on postoperative oxygen levels and comparing the incidence of anastomotic leakage between the groups. The goal is to establish whether hypoxia is a causative risk factor and whether correcting it can reduce the risk of anastomotic leakage.
Eligibility
Inclusion Criteria4
- Patients diagnosed with esophageal carcinoma or benign esophageal tumors
- Patients requiring surgical resection of the lesion with subsequent esophageal reconstruction
- Patients must have had at least one postoperative arterial blood gas analysis
- Patients must have routinely undergone at least one of the following for postoperative evaluation of the anastomosis: endoscopy, CT scan, or esophagram
Exclusion Criteria3
- Patients who did not require esophageal reconstruction
- Patients undergoing esophageal replacement with colon
- Patients with incomplete data
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Locations(6)
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NCT07309991