RecruitingNCT07310537

Feasibility of Circulating Tumour DNA (ctDNA) Analysis Using Automated Capillary Blood Sampling


Sponsor

Erasmus Medical Center

Enrollment

35 participants

Start Date

Nov 17, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to investigate whether circulating tumor-derived DNA (ctDNA) can be reliably detected and analyzed in blood obtained through automated capillary sampling in adult patients (≥21 years) with colorectal liver metastases (CRLM). The main question it aims to answer is: * Can ctDNA be detected in small volumes of capillary blood collected using an automated sampling device? * Do ctDNA levels measured in capillary blood agree with those measured in venous blood from the same patients? Researchers will compare ctDNA measurements from capillary blood to those from venous blood (reference standard) to see if capillary sampling provides reliable results for ctDNA analysis. Participants will: * Provide a small blood sample through automated capillary collection. * Provide a venous blood sample during the same study visit for comparison.


Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a small, wearable device that automatically collects tiny drops of blood (capillary sampling) can be used to detect circulating tumour DNA — tiny fragments of cancer DNA shed into the blood — as a way to monitor colorectal cancer spread to the liver without needing full blood draws. **You may be eligible if...** - You are 21 or older - You have a confirmed history of colorectal cancer that has spread to the liver - You can speak and read Dutch well enough to participate - You have signed informed consent **You may NOT be eligible if...** - You are currently responding to chemotherapy (as this may affect the test) - You have a history of skin infections in the sampling area Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBlood Collection - TAP® Device

K2EDTA BD Microtainer

OTHERBlood Collection - Venous

10 mL EDTA Collection Tube


Locations(1)

Erasmus MC University Medical Center

Rotterdam, South Holland, Netherlands

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NCT07310537


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