A Phase II Trial of LM103 in Advanced Melanoma

This Phase II trial tests a new drug called LM103 in people with advanced melanoma (skin cancer) that has come back or spread and has stopped responding to multiple standard therapies. **You may be eligible if...** - You are between 18 and 75 years old - You have advanced melanoma that cannot be surgically removed (not uveal/eye melanoma) - You have tried at least two lines of standard treatment, including a PD-1 antibody (a type of immunotherapy) - If your melanoma has a BRAF mutation, you have also tried BRAF/MEK inhibitors - You have a life expectancy of more than 3 months and are relatively functional (ECOG 0–1) **You may NOT be eligible if...** - You have uveal (eye) melanoma - You have not previously tried immunotherapy - Your overall health is poor or you have significant organ problems Talk to your doctor to see if this trial is right for you.