RecruitingNCT07313579

Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Gastric Cancer

Observational Prospective Cohort Study on Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Gastric Cancer


Sponsor

Ukrainian Society of Clinical Oncology

Enrollment

200 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The study investigates the outcomes of hyperthermic intraperitoneal chemoperfusion (HIPEC) in combination with curative-intent gastrectomy in resectable locally-advanced and limited-metastatic (low peritoneal cancer index) gastric cancer.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates HIPEC — hyperthermic intraperitoneal chemoperfusion, a procedure where heated chemotherapy is circulated inside the abdomen during surgery — as an additional treatment for gastric (stomach) cancer that has grown into nearby structures or has spread to the lining of the abdomen. **You may be eligible if...** - You are between 18 and 80 years old - You have confirmed stomach cancer (adenocarcinoma by biopsy) - Your tumour has grown deeply through the stomach wall (T4a or T4b) or you have cancer cells in the fluid washed from the abdomen (positive peritoneal cytology) - Your overall health is good (ECOG 0–1) and blood/organ function is adequate **You may NOT be eligible if...** - You are pregnant or breastfeeding - Your overall health is poor (ECOG 2 or worse) - You have inadequate blood counts or organ function Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREcurative-intent surgery + HIPEC

Participants enrolled in this study will undergo curative-intent gastrectomy for gastric cancer, immediately followed by Hyperthermic Intraperitoneal Chemotherapy (HIPEC) performed during the same operative session. Dosage of drugs: mitomycin C 15 mg/m2, cisplatin 75mg/m2. The procedure is conducted according to a standardized protocol in National Cancer Institute


Locations(1)

National Cancer Institute (NCI)

Kyiv, Ukraine

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NCT07313579


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