RecruitingNot ApplicableNCT07315295

Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya

Maximizing the Benefits of Iron in Ready-to-use Therapeutic Foods for Malnourished Children in Kenya


Sponsor

ETH Zurich

Enrollment

68 participants

Start Date

Dec 23, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Reports from the Kenya Red Cross Society (KRCS) in Kwale County, southern Kenya, indicate a limited impact of Ready-to-Use Therapeutic Foods (RUTFs) on malnutrition or anemia. The current RUTF formulation may have an excessively high iron content. In severely acutely malnourished (SAM) children, iron cannot be properly absorbed, leading to life-threatening diarrhea. The overall aim of this project is to develop an improved RUTF treatment that addresses acute malnutrition and anemia in children, ensuring both safety and efficacy. Specifically, to assess the impact of malnutrition on fractional iron absorption (FIA) from RUTFs in children, by comparing healthy children to those with acute malnutrition and by tracking changes in FIA in malnourished children over the course of treatment.


Eligibility

Min Age: 12 MonthsMax Age: 54 Months

Plain Language Summary

Simplified for easier understanding

This study is testing whether changes to the iron content in ready-to-use therapeutic foods (peanut-based pastes used to treat malnutrition) can improve treatment outcomes for malnourished children in Kenya. **You may be eligible if...** - Your child has severe acute malnutrition (very low weight-for-height) or moderate acute malnutrition, and is being treated as an outpatient - OR your child is healthy (normal growth measurements) and serves as a comparison participant - Your child has no acute illness requiring hospitalization and passes an appetite test **You may NOT be eligible if...** - Your child has a hemoglobin level of 7 g/dL or below (severe anemia) - Your child has an acute medical condition that requires hospital admission Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERIron absorption from RUTF on Day 0

RUFT with 57Fe

DIETARY_SUPPLEMENTTreatment with RUTF for 80 days

Daily RUTF intake

OTHERIron absorption from RUTF on Day 20

RUFT with 57Fe

OTHERIron absorption from RUTF on Day 40

RUFT with 57Fe

OTHERIron absorption from RUTF on Day 60

RUFT with 57Fe


Locations(2)

ETH/Oxford/JKUAT research facility

Msambweni, Kwale County, Kenya

ETH Zurich, Laboratory of Clinical Biopharmacy, Zurich, 8092

Zurich, Switzerland

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07315295


Related Trials