Dietary Iron Requirements
Dietary Iron Requirements in US Adults
Pennington Biomedical Research Center
300 participants
Feb 6, 2026
OBSERVATIONAL
Conditions
Summary
Dietary Reference Intakes (DRIs) for iron are based on a relatively small number of studies in European populations. This research study will determine iron needs in a representative sample of adults living in the US using the iron isotope dilution technique. Following administration and equilibration of a stable iron isotope, participants will be followed for a 12 week study period. Blood will be collected every 4 weeks and the isotopic composition will be determined. Results will help update dietary iron guidelines making sure they better match the specific needs of the US population.
Eligibility
Inclusion Criteria7
- Males and premenopausal females age 18-50 y
- Previously participated in an iron stable isotope study or willing to consume an oral stable iron isotope and undergo a one-year equilibration period
- Willing to refrain from iron-containing supplements for the duration of the study
- Willing to refrain from tobacco smoking for the duration of the study
- Have not donated blood 3 months prior to the start of the study and willing to refrain from donating blood for the duration of the study
- Willing to have blood stored for future use
- Able and willing to comply with study requirements and consent to participate
Exclusion Criteria3
- Females: pregnant or lactating or plans to become pregnant during the study period
- Inability to provide informed consent and engage in informed consent procedures
- Plans to relocate outside the study area
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Locations(2)
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NCT07139821