RecruitingPhase 2NCT07318597

Study of REGN13335 in Adult Participants With Pulmonary Arterial Hypertension (PAH)

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of REGN13335, an Anti-PDGF-B Monoclonal Antibody, in Adults With Pulmonary Arterial Hypertension


Sponsor

Regeneron Pharmaceuticals

Enrollment

99 participants

Start Date

May 6, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study is researching an experimental drug called REGN13335. The study is focused on participants with Pulmonary Arterial Hypertension (PAH). The aim of the study is to see how safe and effective REGN13335 is in participants with PAH who are taking other PAH medicines. The study is looking at several other research questions, including: * What side effects may happen from taking REGN13335 * How much REGN13335 is in the blood at different times * Whether the body makes antibodies against REGN13335 (which could make REGN13335 less effective or could lead to side effects)


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Placebo and a drug called REGN13335 for people with pulmonary arterial hypertension pah. The study is currently recruiting participants at 11 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGREGN13335

Administered per the protocol

DRUGPlacebo

Administered per the protocol


Locations(24)

University of Colorado Denver

Aurora, Colorado, United States

Mater Misericordiae Ltd

South Brisbane, Queensland, Australia

Royal Hobart Hospital

Hobart, Tasmania, Australia

UZ Leuven

Leuven, Vlaams-Brabant, Belgium

H.U.B. Erasme Hospital

Brussels, Belgium

Hopital Bicetre

Le Kremlin-Bicêtre, France

Universitatsklinikum Halle

Halle, Saxony-Anhalt, Germany

Clinic of University Greifswald

Greifswald, Germany

Universitatsmedizin Mainz

Mainz, Germany

P. Stradins Clinical University hospital

Riga, Latvia

University Clinical Hospital in Poznan - Early Phase Unit

Poznan, Greater Poland Voivodeship, Poland

University Hospital in Bialystok

Bialystok, Podlaskie Voivodeship, Poland

Oddzial Kardiologiczny

Lodz, Łódź Voivodeship, Poland

Gachon University Gil Medical Center

Namdong-gu, Incheon, South Korea

Asan Medical Center

Seoul, Songpa-gu, South Korea

Seoul National University Hospital

Seoul, South Korea

Severance Hospital

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Hospital Vall d'Hebron

Barcelona, Catalonia, Spain

Hospital Universitario Costa del Sol

Marbella, Malaga, Spain

Hospital Clinic, Barcelona

Barcelona, Spain

University hospital 12 de octubre

Madrid, Spain

Royal United Hospitals Bath NHS Foundation Trust

Bath, United Kingdom

Imperial College Healthcare NHS Trust, Hammersmith Hospital

London, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT07318597


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