Autologous Tenon's Capsule Graft for Refractory Macular Holes
Visual and Anatomical Outcomes of Autologous Tenon's Capsule Graft for Refractory Macular Holes
Benha University
20 participants
Dec 14, 2025
INTERVENTIONAL
Conditions
Summary
This prospective interventional study evaluates the anatomical and functional outcomes of autologous Tenon's capsule grafting in patients with refractory full-thickness macular holes. Eligible patients include those with chronic large macular holes (\>400 µm) or persistent holes following prior pars plana vitrectomy with internal limiting membrane peeling and gas tamponade. Anatomical closure will be assessed using spectral-domain optical coherence tomography, and functional outcomes will be evaluated by best-corrected visual acuity over a 3-month follow-up period.
Eligibility
Inclusion Criteria6
- Age 18 years or older
- Refractory full-thickness macular hole defined as:
- Chronic macular hole >400 µm, or
- Persistent macular hole following prior vitrectomy with ILM peeling and gas tamponade
- Clear ocular media and adequate fixation for OCT imaging
- Ability to provide informed consent
Exclusion Criteria5
- Active ocular infection or inflammation
- Advanced glaucoma or optic neuropathy
- History of intraocular tumors
- Severe proliferative vitreoretinopathy
- Significant systemic diseases likely to affect visual recovery
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Interventions
Participants will undergo 23-gauge pars plana vitrectomy. Autologous Tenon's capsule tissue will be harvested through conjunctival peritomy, trimmed appropriately, and placed into the macular hole using intraocular forceps. Perfluorocarbon liquid may be used for graft stabilization, followed by silicone oil tamponade. Silicone oil removal is planned after 8-12 weeks.
Locations(1)
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NCT07318961