Impact of Emotional Disorders on Response to Immune Checkpoint Inhibitor Therapy in Liver Cancer

This study is looking at whether emotional health — such as anxiety or depression — affects how well liver cancer patients respond to a type of cancer treatment called immune checkpoint inhibitor therapy. Researchers want to understand if treating emotional disorders alongside cancer could improve outcomes. **You may be eligible if...** - You are between 18 and 75 years old - You have been newly diagnosed with liver cancer (hepatocellular carcinoma or intrahepatic cholangiocarcinoma) and have not received any prior treatment - Your liver is functioning reasonably well (Child-Pugh score of 7 or below) - You are generally in good physical condition and able to carry out daily activities **You may NOT be eligible if...** - You have had another type of cancer in the past - Your liver cancer has come back after prior treatment - You have already received systemic (whole-body) cancer treatment - You have liver failure or severe problems with your heart, lungs, or brain - You have a history of severe mental illness - You are currently taking antidepressants or anti-anxiety medications - You are unable to complete questionnaires Talk to your doctor to see if this trial is right for you.