A Prospective Observational Study of First-Line Systemic Therapy Combined With Celiac Plexus Blockade for Advanced Biliopancreatic Cancer With Pain

This study is looking at how well a nerve block procedure called celiac plexus neurolysis — which numbs the nerve cluster near the stomach to reduce cancer pain — works when combined with standard first-line cancer treatment for advanced pancreatic or bile duct cancer. **You may be eligible if...** - You have been diagnosed with advanced pancreatic or bile duct cancer confirmed by biopsy - You have ongoing cancer-related pain scoring 4 or higher on a 0–10 pain scale, lasting more than a week - You are scheduled to receive first-line cancer treatment (such as immunotherapy or chemotherapy) - You are in reasonably good physical condition with a life expectancy of at least 3 months **You may NOT be eligible if...** - You have previously had a celiac plexus nerve block or similar procedure - You have significant clotting problems or very low platelet counts - You have severe heart, liver, or kidney failure - There are local infections or structural issues that make the nerve block unsafe Talk to your doctor to see if this trial is right for you.