RecruitingNCT07328178

Analysis of the Role of IgE Proteoforms in Health and Disease

Sponsor

KU Leuven

Enrollment

200 participants

Start Date

Jan 1, 2025

Study Type

OBSERVATIONAL

Conditions

Anaphylaxis Healthy Control Mastocytosis Chronic Spontaneous Urticaria (CSU)X-linked Agammaglobulinaemia Venom Allergy Type I Allergy Medication Allergy Hereditary Alpha-Tryptasemia

Summary

The goal of this observational study is to evaluate the role of IgE proteoforms in healthy volunteers and in patients with type I allergy, patients with chronic spontaneous urticaria, patients with a recent history of anaphylaxis, patients with mastocytosis, patients with hereditary alpha tryptasemia, patients with X-linked agammaglobulinemia (XLA), and patients undergoing desensitization for venom or medication allergy.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

CSU and type I allergic diseases (including anaphylaxis and desensitization), atopic dermatitis, mastocytosis, XLA and HaT (informed consent, age: any available adult subject, gender: any available subject, clinical phenotype and specific information about the allergy (e.g. severity, medication, medical history, laboratory testing)
Healthy controls (informed consent, age matched to the allergic patients, gender matched to the allergic patients, patient-reported symptoms related to allergy to aeroallergens, food, drugs, hymenoptera venom, CSU)

Exclusion Criteria2

Absence of informed consent
Age < 18 years old

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Interventions

OTHERBlood sample collection

Blood sample collection

Locations(1)

UZ/KU Leuven

Leuven, Vlaams-Brabant, Belgium

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NCT07328178

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