RecruitingNot ApplicableNCT07329361

Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis

Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis: Randomized Control Trial

Sponsor

MiKS Hospital

Enrollment

60 participants

Start Date

Dec 16, 2025

Study Type

INTERVENTIONAL

Conditions

Knee Osteoarthristis

Summary

Evaluation of intra-articular injections in knee osteoarthritis using frozen-stored PRP. Compared with intra-articular injections of PRP applied at the time of collection.

Eligibility

Min Age: 40 YearsMax Age: 85 Years

Inclusion Criteria10

Patients of both sexes.
Aged between 40 and 85 years old.
Diagnosed with osteoarthritis through clinical radiological examination.
Joint pain equal to or less than 75 points on the KOOS (pain).
Radiological severity grades 1, 2, and 3 according to the Ahlbäck scale.
Indication for intra-articular PRP infiltration.
Body Mass Index values between 20 and 35.
Negative serological tests for syphilis, HIV, HBV, and HCV.
Possibility of observation during the follow-up period.
Signature of informed consent.

Exclusion Criteria13

Body mass index \>35
Diagnosed polyarticular disease.
Previous arthroscopy in the last year.
Severe mechanical deformity.
Intra-articular hyaluronic acid injection in the last 12 months.
Intra-articular corticosteroid or PRP injection in the last 6 months.
Systemic autoimmune rheumatic disease (connective tissue diseases and systemic necrotizing vasculitis).
Anemia or other hematological disorders.
Positive serological tests for SYPHILIS, HIV, HBV, and HCV.
Undergoing immunosuppressive treatments.
Poorly controlled diabetes mellitus.
Patients allergic to paracetamol.
Pregnancy or breastfeeding.