RecruitingNot ApplicableNCT07329530

Metabolic and Muscle Profile in ICU Survivors

Characterisation of the Inflammatory, Metabolic, and Mitochondrial Profiles in the Context of Post-Intensive Care Muscle Dysfunction

Sponsor

Anne-Françoise Rousseau

Enrollment

100 participants

Start Date

Dec 1, 2025

Study Type

INTERVENTIONAL

Conditions

Critical Illness Major Abdominal Surgeries

Summary

More and more patients survive a critical illness requiring admission to the intensive care unit, but they may be left with sequelae that are independent of the initial pathology. From a physical standpoint, the most visible complication is intensive care unit-acquired muscle weakness. A major factor in the development and persistence of muscle dysfunction appears to be the inflammatory response and the neuroendocrine stress response triggered by the initial critical insult. Persistence of inflammation beyond ICU discharge has been demonstrated in several studies. In response to inflammation, there is also increased oxidative stress associated with mitochondrial dysfunction. The objectives of the present study are therefore: to determine whether the broad inflammatory and metabolic profile of patients who have survived an ICU stay can predict the trajectory of muscle performance over the three months following ICU discharge; to compare this profile and muscle performance with those of non-critically ill surgical patients who have undergone a standardized inflammatory stress of lower intensity than that associated with critical illness; to investigate mitochondrial function in skeletal striated muscle after ICU stay, in light of the inflammatory and metabolic profile; to assess whether abnormalities in mitochondrial function also affect tissues other than skeletal muscle, in particular circulating blood mononuclear cells.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Critical illness:
anticipated ICU stay >= 7 days
Major abdominal surgery
elective surgery

Exclusion Criteria9

Active malignancy
Inherited metabolic disorder
Known muscle disease
Pregnancy
Patient refusal
Patient unable to express informed consent (dementia, confusion)
Known coagulation disorder (cirrhosis, genetic coagulopathy) or thrombocytopenia < 100,000/mm³ on the day of biopsy, anemia with hemoglobin < 9 g/dL on the day of biopsy, or treatment with anticoagulant agents (contraindication to muscle biopsies only)
Pacemaker or other implanted electronic device (contraindication to bioelectrical impedance analysis only)
Oxygen therapy (contraindication to indirect calorimetry during spontaneous ventilation)

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTInflammation markers

measurement of CRP, cytokines, MPO, oxidative stress during the first 7 days after ICU admission, between 1 and 7 days after ICU discharge and 3 months after ICU discharge (or the day after surgery and 3 months after hospital discharge)

DIAGNOSTIC_TESTBlood nucleosomes

measurement of blood nucleosomes between 1 and 7 days after ICU discharge and 3 months after ICU discharge (or the day after surgery and 3 months after hospital discharge)

DIAGNOSTIC_TESTErythrocyte membrane fatty acid content

assessment of Erythrocyte membrane fatty acid content between 1 and 7 days after ICU discharge and 3 months after ICU discharge (or the day after surgery and 3 months after hospital discharge)

DIAGNOSTIC_TESTmeasurement of myokines

measurement of myokines between 1 and 7 days after ICU discharge and 3 months after ICU discharge (or the day after surgery and 3 months after hospital discharge)

DIAGNOSTIC_TESTResting energy expendure

assessment of REE by indirect caloriometry during the first 7 days after ICU admission, between 1 and 7 days after ICU discharge and 3 months after ICU discharge (or the day after surgery and 3 months after hospital discharge)

DIAGNOSTIC_TESTbody composition

assessment of body composition by BIA during the first 7 days after ICU admission, between 1 and 7 days after ICU discharge and 3 months after ICU discharge (or the day after surgery and 3 months after hospital discharge)

DIAGNOSTIC_TESTOmics

Blood metabolic, lipidomic, proteomic study during the first 7 days after ICU admission (or the day after surgery)

DIAGNOSTIC_TESTMonocyte profile

Blood leukocyte and monocyte profiles and transcriptomic analysis between 1 and 7 days after ICU discharge and 3 months after ICU discharge (or the day after surgery and 3 months after hospital discharge)