Dexamethasone, Dexmedetomidine and Their Combination on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy
Effect of Dexamethasone, Dexmedetomidine and Their Combination on Postoperative Gastrointestinal Function Measured by I-FEED Score After Elective Laparoscopic Cholecystectomy Surgery: a Randomized Controlled Trial
Benha University
160 participants
Dec 15, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to learn the effect of Dexamethasone and Dexmedetomidine and Their Combination on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy What medical problems do participants have when taking Dexamethasone and Dexmedetomidine? Researchers will compare Dexamethasone and Dexmedetomidine and Their Combination to a placebo (a look-alike substance that contains no drug) to see the effect on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy Participants will receive Dexamethasone 8 mg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia. Participants will receive Dexmedetomidine 0.5 mcg /kg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia. Participants will receive Dexamethasone 8 mg IV + Dexmedetomidine 0.5 mcg/kg IV+ Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia. Participants will receive Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia
Eligibility
Inclusion Criteria4
- Age 18-65 years.
- American Society of Anesthesiologists (ASA) physical status I or II.
- Scheduled for elective laparoscopic cholecystectomy surgery under general anesthesia.
- Ability to provide written informed consent
Exclusion Criteria9
- Known allergy or contraindication to any study drug (dexamethasone, dexmedetomidine, or placebo).
- Pre-existing gastrointestinal motility disorders (e.g., gastroparesis, inflammatory bowel disease).
- Chronic use of opioids, steroids, or antiemetics.
- History of severe cardiac disease (e.g., high-grade AV block, severe bradycardia).
- Uncontrolled diabetes mellitus (HbA1c > 8.0%).
- Emergency surgery or conversion to open surgery.
- Pregnancy or breastfeeding.
- Morbid obesity (BMI >40).
- Severe hepatic or renal dysfunction.
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Interventions
Participants will receive Dexamethasone 8 mg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Participants will receive Dexmedetomidine 0.5 mcg /kg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Participants will receive Dexamethasone 8 mg IV + Dexmedetomidine 0.5 mcg/kg IV+ Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia
Participants will receive Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07329933